It is a typical double-edged sword that Pristine can improve renal function and cause acute renal failure and hyperkalemia.
Uncle Chen is 57 years old and has been in good health. Because living in the countryside, often do physical work, physical fitness is good. But in the countryside, more or less, they will become addicted to smoking. Uncle Chen's addiction to smoking was mainly formed three years ago. He used to smoke before, but he was able to control it.
Three years later, Uncle Chen raised his blood pressure with cigarettes. Due to the frequent symptoms of dizziness and headache, Uncle Chen, accompanied by his family, went to the hospital for examination and treatment. As a result, he found high blood pressure, with systolic blood pressure as high as 160mmhg.
Taking medicine is necessary, and there is no choice, so Uncle Chen started his journey of taking medicine to reduce blood pressure, but no one thought that it was only nine months after taking antihypertensive drugs, and there was no abnormality. At the age of 57, Uncle Chen suddenly suffered from renal failure and was admitted to ICU. What's going on?
Is there anything wrong with the medicine?
The medicine prescribed by the doctor is benazepril hydrochloride, which is a commonly used antihypertensive drug. There is no mistake! What's more surprising is that April drugs can protect renal function. Why do they have sudden renal failure? This should start with April drugs!
Pril drugs, namely angiotensin-converting enzyme inhibitors, are a class of antihypertensive drugs and anti heart failure drugs. Its pharmacological action is to inhibit the activity of the angiotensin-converting enzyme, inhibit the conversion of angiotensin-converting enzyme I to angiotensin-converting enzyme II, act on bradykinin system, inhibit the degradation of bradykinin, to dilate blood vessels, reduce blood pressure, reduce cardiac afterload, protect target organs, improve left ventricular function and eliminate oxygen free radicals.
It is a typical double-edged sword that Pristine can improve renal function and cause acute renal failure and hyperkalemia. In general, April drugs can improve renal hemodynamics, improve renal salt secretion, and slow down the development of chronic kidney disease and kidney injury. In this case, why did Uncle Chen have sudden renal failure?
Is Uncle Chen wrong?
It turned out that Uncle Chen always had kidney disease, but he didn't tell the doctor because he didn't think it was related to hypertension. Because of this, Uncle Chen's medication history has become a history of kidney injury. It should be noted that April drugs should be paid special attention to patients with kidney disease. It is emphasized in the consensus on the correct use of April drugs in patients with nephropathy than the serum creatinine should be observed within the first two months of medication. If the long-term increase of serum creatinine is less than 30%, there is no need to stop the medication.
If the increase of serum creatinine is more than 30%, it indicates renal ischemia and should be stopped. And Uncle Chen did not test serum creatinine, just blindly listen to the doctor, adhere to medication. Don't you know, only when the serum creatinine level returns to the level before medication, can we continue to use Pristine drugs.
After nine months of medication, Uncle Chen suddenly suffered from renal failure without any abnormality. This is also in line with scientific principles. Certain quantitative changes cause qualitative changes, but the cost is too heavy. This is also a wake-up call for future generations. I hope this kind of thing will not happen again.
For April drugs, pharmacist Wang would like to give a brief introduction. I hope you have a systematic understanding.
In the first generation of captopril, the mercapto group was the core group, and captopril was the representative drug;
The core group of the second generation of April is the carboxyl group, and the representative drugs are enalapril, benazepril, and perindopril;
The core group of the third generation of April is Mercaptophosphoryl and the representative drug is fosinopril.
What diseases are April drugs suitable for?
1. It is suitable for patients with decreased heart function and heart failure. Pril drugs have certain cardiac protective effects, which can prevent and delay the occurrence of heart failure and reduce the mortality of patients with heart failure.
2. For hypertension patients with proteinuria, diabetes, and diabetic nephropathy, April drugs can reduce renal blood flow resistance and delay renal damage.
3. For patients with a high risk of atherosclerosis or coronary heart disease, April drugs have a clear protective effect on the heart, and can also eliminate oxygen free radicals and regulate blood lipids, which is conducive to slow down the process of atherosclerosis.
