With the continuation of novel coronavirus prevalence, researchers are eager to know whether hypertension or its drugs interact with viruses.
So far, the new coronavirus, sars-Nov-2, has reached all continents except Antarctica. The disease it causes - the new coronavirus - has killed thousands of people.
In recent weeks, medical experts have published hundreds of papers on various aspects of the disease. Recent comments appear in
American Journal of hypertension
Look at high blood pressure.
In general, the authors conclude that, in the current situation, there is no conclusive evidence that high blood pressure or blood pressure drugs increase a person's risk of sars-Nov-2 infection. Similarly, current evidence does not support the theory that people with high blood pressure are more likely to develop more severe symptoms if they are infected with the new coronavirus.
Existing conditions and novel coronavirus
Studies have shown that some existing conditions are associated with an increased risk of sars-Nov-2 infection and more severe symptoms of the new coronavirus.
For example,
study
A survey of 41 patients in Wuhan, China, found that 32% of the patients had potential health conditions - the most common were diabetes, hypertension, and cardiovascular disease.
Another study appeared
JAMA
internal medicine
The novel coronavirus was tracked in 201 people. Of these, 84 developed acute respiratory distress syndrome (ARDS). Hypertension was found in 27.4% of 84 ARDS patients. In contrast, 13.7% of the patients without ARDS had hypertension.
However, these novel coronavirus related to hypertension is not necessarily causal. As the author of the recent commentary explains:
The novel coronavirus is a common disease in the elderly. [H] is often abnormal in the elderly. The elderly seem to be particularly likely to infect the SARS-CoV-2 virus and to develop serious forms and complications of the new coronavirus. "
stay
JAMA
The results showed that the average age of individuals with ARDS was 58 years old, while the average age of individuals without ARDS was 48 years old. In conclusion, the novel coronavirus risk and hypertension need further study.
Hypertension drugs
For patients with hypertension, doctors sometimes prescribe angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). These drugs belong to a group of drugs called the renin-angiotensin-aldosterone system (RAAS) antagonists
These drugs block the activity of a receptor called RAAS 2. Scientists
Show
Sars-cov-2 binds to the ACE-2 receptor and promotes its entry into lung cells. This coincidence raises some interesting questions.
There is evidence that ACE inhibitors and ARBs increase the number of ACE 2 receptors. As the author explained, this "theoretically increases the binding of sars-Nov-2 to the lung and its pathophysiological effects, leading to greater lung injury.". In other words, if these drugs increase the number of virus entry points, they may cause more severe symptoms.
However, contrary to this theory,
Research
It is suggested that ACE 2 has a protective effect on severe lung injury. Following a similar line of thought, the authors of the recent review explained that due to the interaction with RAAS, both ACE inhibitors and ARBs may "help to systematically reduce inflammation, especially in the lung, heart, and kidney."
If so, these drugs "may reduce the development potential of acute respiratory distress syndrome, myocarditis or acute kidney injury, which may occur in patients with emerging coronavirus."
In fact, some researchers
proposal
ARBS is a novel coronavirus as a potential therapeutic method.
Other researchers
Proposed number
Soluble ACE 2 was used as a treatment. When sars-Nov-2 binds to the Ace 2 receptor, the increase of circulating ACE 2 level may help to "clear" the virus and prevent it from reaching the lung and other organs carrying the ACE 2 receptor.
So far, however, researchers have not tested these methods in humans.
At present, the official agency recommends the continued use of drugs to treat high blood pressure. For example, the American Heart Failure Association, the American Heart Association, and the American Heart Association
recommend
Continue to use RAAS antagonists for those currently prescribed for indications that are considered beneficial, such as heart failure, hypertension, or ischemic heart disease.
On the whole, there are still many problems. So far, there is not enough evidence to confirm that hypertension increases the risk of new coronaviruses. As for novel coronavirus, they may prevent SARS-CoV-2, make the new coronavirus more serious, or not affect infection at all. The authors of the new commentary conclude that:
"So far, novel coronavirus is not related to hypertension, or the use of ACE inhibitors or ARB during the epidemic of new coronavirus is harmful or beneficial."